Folding the chart so that you can easily refold it along your route is part of the pre-flight planning.
Of course, if you fly on a long diagonal track, you will struggle but for most purposes, it works quite well.
However, if you're not scared of taking a knife to your chart, with well judged folding and cutting you use the Falk folding technique to fold it like a book and leaf up/down and left/right with impunity. Again, the UK charts are good for this - the lamination is not stiff and stops the paper from ripping. A sharp knife is all that is required to make a Falk 'book'.
Here is the the original Falk technique:
Applied to the UK Southern chart and choosing to make it 4 'pages' tall and 5 'pages' wide, you get this nifty booklet (with my markings visible):
Opening it up on London, it looks like this:
You can fold up and across to the north east:
And then down to the south west:
For planning purposes, it unfolds to be a complete chart when you have the space for it, although you need to be mindful of the cuts when you draw on it, so you do not mark the table underneath.
You could of course centre it somewhere else and/or choose a different size than the 4 x 5 I did...
So, there's no excuse!
Morten
We all live under the same sky, but we don't all have the same horizon.